Hey Glaxo...and your highly paid Devil advocates. Whilst in Toronto I picked up a disc full of Paxil articles, studies, case reports etc. I have enough here to keep me occupied for a good few months. The disc has many articles on withdrawal and suicides - it's tough reading, particularly as I have endured the horrific side effects of withdrawal from that toxic drug of yours. It's particularly tough reading because of the suicide articles and papers too. I've also been privy to listen to heart wrenching stories from parents your drug paroxetine has had a hand in causing loss of life too. That irks me somewhat so you'll forgive me for rehashing this old Lancet article, I'm sure.
It was published in 1995, even back then you were denying there was a problem with your wonder drug.
You know, history has a way of catching up with you. It often bites you on the ass...pretty hard. [Cue Devil advocates to start muck spreading via their puppets and/or honey traps]
Two healthy white men, aged 36 and 48 years, participated in a controlled double-blind clinical trial of paroxetine treatment for stuttering.
Both had a history of brief episodes of minor depression.
After completing a 6- week treatment period with 50 mg paroxetine, both men went into a placebo phase. In the first case, 2 days after abrupt drug discontinuation, the subject reported hypomanic-like symptoms, including hyperactivity, decreased need for sleep, and irritability that developed into agitation, aggressiveness, and volatility.
After 2 weeks of fluctuating symptoms, he experienced ego-dystonic impulsive behaviour such as shoplifting and suicidal impulses and gestures. All symptoms abated spontaneously after 2i weeks.
In the second case, paroxetine was tapered over a 12-day period. The first week of withdrawal was notable for an uncharacteristic feeling of confidence and optimism, talkativeness, and a subjective feeling of sharpened and quickened thought processes.
During the 2nd week, the patient developed physical symptoms of dizziness, blurred vision, nausea, lethargy, and insomnia. He also reported feeling angry, irritable, and short-tempered, with some highly atypical explosive vocal outbursts and tantrums. He became preoccupied with homicidal thoughts and plans, initially directed towards acquaintances and later towards his own children. These became so intense and egodystonic that he contemplated suicide.
Physical and behavioural symptoms lasted about 9 days and then remitted spontaneously over 2-3 days.
In these two instances, men without a history of major psychiatric disorder developed severe behavioural symptoms when paroxetine was withdrawn.
The first few days were characterised by predominantly hypomanic features followed by a period of escalated ego-dystonic aggression, behaviouraldyscontrol, and suicidal intention. This biphasic symptom pattern is reminiscent of the case of fluvoxamine precipitated withdrawal hypomania described by Szabadi.
We believe that the serious behavioural symptoms seen in these cases were adverse effects of paroxetine withdrawal.
Vol 346. July 1995 - The Lancet
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