Atomoxetine (Strattera) for ADHD: risk of psychotic or manic symptoms

The Medicines and Healthcare products Regulatory Agency (MHRA) has published Drug Safety Update for March 2009. One of the drugs reviewed is atomoxetin (Strattera), a SNRI used for the treatment of ADHD. These are the recommendations:

Advice for healthcare professionals:

• At normal doses, atomoxetine can be associated with treatment-emergent psychotic or manic symptoms (eg, hallucinations, delusional thinking, mania, or agitation) in children and adolescents without a history of psychotic illness or mania.

• If such symptoms occur , consideration should be given to a possible causal role of atomoxetine and discontinuation of treatment.

• It remains possible that atomoxetine might exacerbate pre-existing psychotic or manic symptoms.

Fid


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